Transit time and intraluminal pH after ileocecal resection

What is known

• Measured with pH-sensitive radiocapsules in nine ileocecal-resected CD patients vs 13 healthy volunteers. ¹
• The shorter transit is attributed mainly to loss of the ileocecal valve, largely independent of resected ileum length or time since resection. ¹
• Reduced time above pH 5.5-7.0 may affect delivery of drugs from pH-dependent tablet formulations. ¹

What is unknown / caveats

• Single small case-control study (n=9 vs 13)
• No correlation found between transit time and resected ileum length or time elapsed since surgery
• Findings rest on one small 1998 case-control study, so precision and generalizability are limited.

References

1. Fallingborg J, Pedersen P, Jacobsen BA. Small intestinal transit time and intraluminal pH in ileocecal resected patients with Crohn's disease. Dig Dis Sci. 1998;43(4):702-5. PMID: 9558022.

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