Isolated gastric involvement in CD

What is known

• Two overlapping reviews state isolated stomach involvement accounts for less than 0.07% of all gastrointestinal CD. ^1,2
• A case report cites isolated gastric CD in 0.7% of CD patients and gastroduodenal involvement in under 5%, usually with concurrent terminal ileal or colonic disease. ³
• Ileocolonic/colonic disease accounts for ~40% and small-bowel for ~30% of CD; the stomach is rarely the sole or predominant site. ^1,2

What is unknown / caveats

• Figures differ tenfold across sources: <0.07% ^1,2 vs 0.7% ³
• All supporting sources are case reports/narrative backgrounds, not epidemiologic cohorts
• The discrepant proportions may reflect differing definitions of 'isolated' gastric vs gastroduodenal disease
• The exact proportion is not established from cohort data and the cited figures span an order of magnitude.

References

1. Ingle SB, Hinge CR, Dakhure S, Bhosale SS. Isolated gastric Crohn's disease. World J Clin Cases. 2013;1(2):71-3. PMID: 24303469.

2. Ingle SB, Adgaonkar BD, Jamadar NP, Siddiqui S, Hinge CR. Crohn's disease with gastroduodenal involvement: Diagnostic approach. World J Clin Cases. 2015;3(6):479-83. PMID: 26090366.

3. Balendran K, Udumalagala S, Nawaraththne NMM. Pyloric stenosis as a manifestation of isolated gastric Crohn's disease responding to intralesional steroid injection and balloon dilation: a case report. J Med Case Rep. 2019. PMID: 31718712.

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Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct.